神經(jīng)營(yíng)養(yǎng)因子以及受體PCR芯片可用于研究與神經(jīng)元過(guò)程相關(guān)的84個(gè)關(guān)鍵基因的表達(dá)。該芯片包含神經(jīng)營(yíng)養(yǎng)信號(hào)分子包括神經(jīng)營(yíng)養(yǎng)因子和神經(jīng)肽,以及它們的受體。參與神經(jīng)系統(tǒng)正常功能的基因如:神經(jīng)細(xì)胞生長(zhǎng),分化,神經(jīng)再生和存活相關(guān)的基因也包含在這張芯片里。參與神經(jīng)信號(hào)的細(xì)胞因子和受體,神經(jīng)沖動(dòng)傳導(dǎo)的基因,神經(jīng)營(yíng)養(yǎng)因子和轉(zhuǎn)錄因子調(diào)控的細(xì)胞凋亡相關(guān)基因和和神經(jīng)系統(tǒng)下游通路的活性的調(diào)節(jié)因子。利用實(shí)時(shí)定量PCR,研究者可以方便并且可信地對(duì)與神經(jīng)系統(tǒng)相關(guān)的基因進(jìn)行同時(shí)檢測(cè)。 Neurotrophins and Receptors: ADCYAP1R1, ARTN, BDNF, CD40 (TNFRSF5), CNTF, CNTFR, CRHBP, CRHR1, CRHR2, FRS2, FRS3, FUS, GDNF, GFRA1, GFRA2, GFRA3, GMFB, GMFG, MAGED1, MT3, NF1, NGF, NGFR, NGFRAP1, NR1I2, NRG1, NRG2, NTF3, NTF4, NTRK1, NTRK2, PSPN, PTGER2, TFG, TRO, VGF. Neuropeptides and Receptors: Neuropeptide Hormone: CRH, NPFF, NPY, PNOC, UCN. Bombesin Receptors: GRPR. Cholecystokinin Receptors: CCKAR. Galanin Receptors: GALR1, GALR2. Neuropeptide Y Receptors: NPY1R, NPY2R, PPYR1. Neurotensin Receptors: NTSR1. Tachykinin and Receptors: TACR1. Other Neuropeptides and Receptors: NPFFR2 (GPR74), HCRT, MC2R. Neurogenesis: Central Nervous System Development: PSPN. Peripheral Nervous System Development: GFRA3. Negative Regulation of Neurogenesis: MT3. Other Neurogenesis Related Genes: ARTN, BDNF, CBLN1, CNTF, CNTFR, FGF2, GDNF, MEF2C, NELL1, NGFR, NRG1, NTF3, NTRK1, NTRK2, STAT3, TFG. Transmission of Nerve Impulse: CBLN1, CNTF, CRH, GALR1, GALR2, HCRT, NPFF, NPY, NTSR1, PNOC. Cell Growth and Differentiation: Growth Factors and Receptors: ARTN, BDNF, CNTF, FGF2, FGF9, FGFR1, FRS2, FRS3, GDNF, GMFB, GMFG, IL10, IL1B, IL6, LIF, NGF, NRG1, NRG2, NRG4, NTF3, NTF4, PSPN, TGFA, TGFB1, VGF. Cell Cycle: BAX, BCL2, FGF2, FGF9, IL1B, MYC, NF1, STAT1, TGFA, TGFB1, TP53. Cell Proliferation: BCL2, FGF2, FGF9, GRPR, IL10, IL1B, IL6, IL6R, LIF, MT3, MYC, NF1, NPY, TGFA, TGFB1, TP53. Cell Differentiation: FGF9, IL10, NRG1, TP53. Cytokines and Receptors: CNTFR, CX3CR1, CXCR4, IL10, IL10RA, IL1B, IL1R1, IL6, IL6R, IL6ST, LIF, LIFR. Apoptosis: Anti-Apoptosis: BCL2, FAS (TNFRSF6), GDNF, IL10, NRG2, NTF3, TGFB1. Caspase Activation: STAT1, TP53. Induction of Apoptosis: BAX, FAS (TNFRSF6), TP53. Other Genes Related to Apoptosis: CD40 (TNFRSF5), HSPB1, IL1B, NGFR, NGFRAP1. Immune Response: Acute-Phase Response: IL6, STAT3. Humoral Immune Response: BCL2, CD40 (TNFRSF5), IL10, IL1B, IL6. Inflammatory Response: CD40 (TNFRSF5), FOS, IL10, IL1B, IL1R1, TACR1. Other Immune Response Genes: FAS (TNFRSF6), CRH, CRHR1, CX3CR1, IL6R, IL6ST, LIF. Transcription Factors and Regulators: RNA Polymerase II Transcription Factors: FOS, MEF2C. Transcription Coactivators: MEF2C, NR1I2. Transcription Factors: MEF2C, MYC, NR1I2, STAT1, STAT2, STAT3, STAT4, TP53. |