胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
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| 地區(qū)： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱： | PCR芯片 |
胰島素信號通路PCR芯片可檢測與胰島素反應(yīng)有關(guān)的84個(gè)基因。芯片包含了與胰島素受體有關(guān)的基因和胰島素信號通路的靶基因，碳水化合物、脂類、蛋白代謝有關(guān)的基因和相關(guān)的生物學(xué)反應(yīng)有關(guān)的基因也包括在內(nèi)。此外，芯片還包含PI3K和MAPK信號通路的成員。通過實(shí)時(shí)定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時(shí)檢測胰島素反應(yīng)相關(guān)的基因表達(dá)。 Insulin Receptor-Associated Proteins: Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1. Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1. SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1. Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1. PI-3 Kinase Pathway: Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, MTOR, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, PRKCZ. Target Genes: BCL2L1, DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1, SLC2A4, SREBF1, UCP1, VEGFA MAPK Pathway: Components: ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1, RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1. Target genes: ANG, BCL2L1, ERCC1, FOS, LDLR, NOS2, UCP1. Primary Target Genes for Insulin Signaling: CEBPA, CEBPB, FOS, JUN, LEP, PRL. Secondary Effector Target Genes for Insulin Signaling: NPY, PCK2, SLC2A1, SLC2A4, TG. Target genes for PPARg: ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN. Target genes for SREBP1: ACACA, FBP1, G6PC, GCK, PCK2, PKM2. Carbohydrate Metabolism: Glucose Metabolism: FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM2, SLC2A1, SLC2A4, SORBS1. Glycogen Metabolism: G6PC, GSK3B, PPP1CA. Other Genes Related to Carbohydrate Metabolism: ADRB3, GPD1, INSR. Lipid Metabolism: Cholesterol Metabolism:LDLR, SREBF1. Fatty Acid Metabolism: ACACA, ACOX1, FASN. Lipid Transport: LDLR, SORBS1. Other Lipid Metabolism Genes: ARAF, BRAF, INS, LEP, PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1. Protein Metabolism: Protein Amino Acid Dephosphorylation: DUSP14, PPP1CA, PTPN1, PTPRF. Protein Amino Acid Phosphorylation: AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1, PDPK1, PRKCG, PRKCI, PRKCZ, RAF1, RPS6KA1. Protein Biosynthesis: ANG, EIF2B1, EIF4EBP1, LDLR, PPP1CA. Protein Transport: PRKCI, RRAS2. Other Protein Metabolism Genes: AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2, SORBS1, VEGFA. Transcription Factors and Regulators: DNA-dependent Regulation of Transcription: CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1. RNA Polymerase II Transcription Factor Activity: CEBPA, FOS, JUN, SREBF1. Transcription Factors: AEBP1, CBL, CEBPA, CEBPB, JUN, PPARG, SREBF1. Cell Growth and Differentiation: Cell Cycle: MTOR, HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1, VEGFA. Cell Proliferation: GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA. Growth Factors and Receptors: GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGFA. Cell differentiation: NOS2, PPARG |
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