cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片 cAMP/Ca2+ PathwayFinder PCR Array
cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片 cAMP/Ca2+ PathwayFinder PCR Array
cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片 cAMP/Ca2+ PathwayFinder PCR Array
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| 地區(qū)： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片 |
芯片可用于研究參與cAMP/Ca2+應答的84的關鍵基因的表達。這一芯片所包含的基因，其啟動子區(qū)域具有SRE或SRE-like增強子序列、CRE增強子序列或其他Ca2+應答元素。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測cAMP/Ca2+信號通路相關基因的表達。 Genes whose promoters contain SRE or SRE-like enhancer sequences: CNN1 (calponin), CYR61, EGR1, EGR2, FOS, FOSB, HSPA4 (hsp70), JUNB, NR4A2 (Nur77), S100A6 (Calcyclin), SCG2 (secretogranin II), SRF, THBS1 (TSP-1), VCL. Genes whose promoters contain the CRE enhancer sequence: Neuropeptides / Neurotransmitters: ADRB1 (b1 adrenergic receptor), CGA (Chorionic gonadotropin A), CHGA (Chromogranin), GCG (Glucagon), GIPR, INHBA (Inhibin A), KCNA5 (KV1.5), NOS2 (Inducible nitric oxide synthase), PENK (Enkephalin), PRL, S100A12 (CGRP), S100G, SCG2, SLC18A1 (Vesicular monoamine transporter), SST (Somatostatin), SSTR2 (Somatostatin receptor 2), TACR1 (Substance P receptor), TH(Tyrosine hydroxylase), VIP. Cell Cycle / Cell Survival / DNA Repair: BCL2, BRCA1, CCNA1 (CyclinA), CCND1 (CyclinD1), CDK5, CDKN2B (p15IND4b), GEM, NF1, PCNA, PMAIP1 (NoxA), PPP1R15A (GADD34), RB1. Growth Factor: AREG (Amphiregulin), BDNF, CTF1 (Cardiotrophin), FGF6, TGFB3, TNF. Signaling: DUSP1 (Ptpn16), HSPA5 (Grp78), PLN (Phospholamban), PPP2CA (Protein phosphatase 2A alpha), PRKAR1A (Proteinkinase A regulatory subunit), SGK1. Transcription: ATF3, CREB1, CREM, EGR1, EGR2, FOS, JUND, MAF, NR4A2 (Nur77), PER1, POU1F1 (Pit-1), POU2AF1 (OCA-B), STAT3. Metabolism: AHR, AMD1, ENO2, HK2, LDHA, PCK2, SOD2. Immune Regulation: IL2, IL6, MIF, PTGS2 (Cox-2). Genes whose promoters contain other Ca2+ responsive elements: CALB1 (calbindin 1), CALB2 (calbindin 2), CALM1 (Calmodulin 1), CALR (Calreticulin), DDIT3 (GADD153), NCAM1, NPY, PLAT (tPA). |
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