抗細(xì)菌反應(yīng)PCR芯片 Antibacterial Response PCR Array
抗細(xì)菌反應(yīng)PCR芯片 Antibacterial Response PCR Array
抗細(xì)菌反應(yīng)PCR芯片 Antibacterial Response PCR Array
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| 地區(qū)： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱(chēng)： | PCR芯片 |
抗細(xì)菌反應(yīng)PCR芯片可用于研究參與細(xì)菌先天免疫反應(yīng)的84個(gè)關(guān)鍵基因的表達(dá)。三個(gè)不同家族模式識(shí)別受體（TLRs、NLRS、RIG-I樣受體）能啟動(dòng)先天免疫，從而識(shí)別常見(jiàn)病原體如細(xì)菌等。TLRs、NLRS和其它PRRS可以識(shí)別細(xì)菌病原體的特征分子，如脂多糖（LPS）、肽聚糖和鞭毛。PAMP受體結(jié)合并激活先天免疫反應(yīng)，啟動(dòng)下游信號(hào)，并誘導(dǎo)炎性細(xì)胞因子的表達(dá)。免疫細(xì)胞和上皮細(xì)胞分泌的抗菌肽對(duì)先天免疫應(yīng)答也有幫助。它們可以作為免疫細(xì)胞的趨化因子，直接破壞病原體的細(xì)胞膜，同時(shí)激活PRR信號(hào)通路。這一芯片包含了參與細(xì)菌活性PRR信號(hào)轉(zhuǎn)導(dǎo)的基因，對(duì)炎癥和細(xì)胞凋亡有重要作用的下游效應(yīng)蛋白的基因，和在免疫細(xì)胞表達(dá)的抗菌肽基因。通過(guò)實(shí)時(shí)定量PCR的方法，研究者即能夠利用該芯片簡(jiǎn)單可靠地同時(shí)檢測(cè)抗細(xì)菌反應(yīng)相關(guān)基因的表達(dá)，研究對(duì)細(xì)菌病原體的先天免疫的機(jī)制。
Toll-like Receptor (TLR) Signaling: Receptors & Cofactors: CD14, LY96 (MD-2), TLR1, TLR2, TLR4, TLR5, TLR6, TLR9. MYD88-Dependent: FADD, IRAK1, IRAK3, IRF5, IRF7, MAP3K7 (TAK1), MYD88, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TOLLIP, TRAF6. TICAM1 (TRIF) Dependent (MYD88-Independent): IRF5, IRF7, MAP3K7 (TAK1), RIPK1, TICAM1 (TRIF), TICAM2 (TRAM), TLR4, TRAF6. Other: AKT1, CASP8 (FLICE), LBP, PIK3CA (p110a), RAC1. NOD-like Receptor (NLR) Signaling: Receptors: NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, NOD1 (CARD4), NOD2. Inflammasomes: CASP1 (ICE), NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, PYCARD (TMS1/ASC). Regulation: BIRC3 (c-IAP1), CARD6, CARD9, CASP8 (FLICE), HSP90AA1, MEFV, PSTPIP1,RIPK2, SUGT1, TNF, XIAP. Other Bacterial Pattern Recognition Receptors (PRRs): APCS, CRP, DMBT1, ZBP1. Downstream Signal Transduction: NF?B Pathway: CHUK (IKKa), IKBKB, NFKB1, NFKBIA (IkBa/MAD3), RELA, TNFRSF1A. ERK Pathway: JUN, MAP2K1 (MEK1), MAPK1 (ERK2), MAPK3 (ERK1). p38/JNK Pathway: JUN, MAP2K3 (MEK3), MAP2K4 (JNKK1), MAPK14 (p38 MAPK), MAPK8 (JNK1). Apoptosis: AKT1, BIRC3 (c-IAP1), CARD6, CARD9, CASP1 (ICE), CASP8 (FLICE), CD14, FADD, IFNB1, IKBKB, IL12A, IL12B, IL1B, IL6, IRAK1, JUN, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK8 (JNK1), MPO, NFKB1, NFKBIA (IkBa/MAD3), PIK3CA, PYCARD, RAC1, RIPK1, RIPK2, TNF, TNFRSF1A, TRAF6. Inflammatory Response: AKT1, APCS, CCL3 (MIP-1A), CCL5 (RANTES), CD14, CRP, CXCL1, CXCL2, IL1B, IL6, IL8, LBP, LY96 (MD-2), LYZ, MEFV, MYD88, NFKB1, NLRC4, NLRP3, NOD1 (CARD4), RAC1, RELA, RIPK2, SLC11A1, TICAM2 (TRAM), TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TNF, TNFRSF1A, TOLLIP. Cytokines & Chemokines: CCL3 (MIP-1A), CCL5 (RANTES), CXCL1, CXCL2, IFNA1, IFNB1, IL12A, IL12B, IL18, IL1B, IL6, IL8. Antimicrobial Peptides: BPI, CAMP, CTSG, LCN2 (NGAL), LTF, LYZ, MPO, PRTN3, SLPI |
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