阿爾茲海默癥PCR芯片包含了84個可用于研究老年癡呆癥發(fā)生與發(fā)展的重要基因。芯片中包括與β-淀粉樣蛋白（Aβ）的產生、清除和降解有關的基因，還包括β-淀粉樣蛋白（Aβ）信號轉導途徑中參與神經毒性和炎癥反應的基因。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測阿爾茲海默癥相關基因的表達。
| Alzheimer’s Disease PCR Array阿爾茲海默癥PCR芯片 |
Beta-Amyloid Generation, Oligomerization, Clearance, & Degradation: Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2. Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG. Endocytosis: APLP1, APP, LRP1, LRP6, LRP8. Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1. Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI. Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT. Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB. Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE , PRKCZ, PSEN1, PSEN2, SNCA. Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA. Cell Signaling Molecules: WNT Signaling: GSK3A, GSK3B, LRP6. Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2. G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2. Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2. Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA). Transcription: APBB1, APBB2, EP300, ERN1. Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2. Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL1, SERPINA3, UQCRC2. |
