抗細菌反應PCR芯片 Antibacterial Response PCR Array

科技服務 > PCR芯片實驗服務 > 抗細菌反應PCR芯片 Antibacterial Response PCR Array

抗細菌反應PCR芯片 Antibacterial Response PCR Array

抗細菌反應PCR芯片 Antibacterial Response PCR Array
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地區(qū):上海
提供商:SABio
服務名稱:PCR芯片
抗細菌反應PCR芯片可用于研究參與細菌先天免疫反應的84個關鍵基因的表達。三個不同家族模式識別受體(TLRs、NLRS、RIG-I樣受體)能啟動先天免疫,從而識別常見病原體如細菌等。TLRs、NLRS和其它PRRS可以識別細菌病原體的特征分子,如脂多糖(LPS)、肽聚糖和鞭毛。PAMP受體結合并激活先天免疫反應,啟動下游信號,并誘導炎性細胞因子的表達。免疫細胞和上皮細胞分泌的抗菌肽對先天免疫應答也有幫助。它們可以作為免疫細胞的趨化因子,直接破壞病原體的細胞膜,同時激活PRR信號通路。這一芯片包含了參與細菌活性PRR信號轉導的基因,對炎癥和細胞凋亡有重要作用的下游效應蛋白的基因,和在免疫細胞表達的抗菌肽基因。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測抗細菌反應相關基因的表達,研究對細菌病原體的先天免疫的機制。
 
Antibacterial Response PCR Array
抗細菌反應PCR芯片
HumanPAHS-148Z
MousePAMM-148Z
RatPARN-148Z
ChickenPAGG-148

Toll-like Receptor (TLR) Signaling: Receptors & Cofactors: CD14, LY96 (MD-2), TLR1, TLR2, TLR4, TLR5, TLR6, TLR9. MYD88-Dependent: FADD, IRAK1, IRAK3, IRF5, IRF7, MAP3K7 (TAK1), MYD88, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TOLLIP, TRAF6. TICAM1 (TRIF) Dependent (MYD88-Independent): IRF5, IRF7, MAP3K7 (TAK1), RIPK1, TICAM1 (TRIF), TICAM2 (TRAM), TLR4, TRAF6. Other: AKT1, CASP8 (FLICE), LBP, PIK3CA (p110a), RAC1. NOD-like Receptor (NLR) Signaling: Receptors: NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, NOD1 (CARD4), NOD2. Inflammasomes: CASP1 (ICE), NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, PYCARD (TMS1/ASC). Regulation: BIRC3 (c-IAP1), CARD6, CARD9, CASP8 (FLICE), HSP90AA1, MEFV, PSTPIP1,RIPK2, SUGT1, TNF, XIAP. Other Bacterial Pattern Recognition Receptors (PRRs): APCS, CRP, DMBT1, ZBP1. Downstream Signal Transduction: NF?B Pathway: CHUK (IKKa), IKBKB, NFKB1, NFKBIA (IkBa/MAD3), RELA, TNFRSF1A. ERK Pathway: JUN, MAP2K1 (MEK1), MAPK1 (ERK2), MAPK3 (ERK1). p38/JNK Pathway: JUN, MAP2K3 (MEK3), MAP2K4 (JNKK1), MAPK14 (p38 MAPK), MAPK8 (JNK1). Apoptosis: AKT1, BIRC3 (c-IAP1), CARD6, CARD9, CASP1 (ICE), CASP8 (FLICE), CD14, FADD, IFNB1, IKBKB, IL12A, IL12B, IL1B, IL6, IRAK1, JUN, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK8 (JNK1), MPO, NFKB1, NFKBIA (IkBa/MAD3), PIK3CA, PYCARD, RAC1, RIPK1, RIPK2, TNF, TNFRSF1A, TRAF6. Inflammatory Response: AKT1, APCS, CCL3 (MIP-1A), CCL5 (RANTES), CD14, CRP, CXCL1, CXCL2, IL1B, IL6, IL8, LBP, LY96 (MD-2), LYZ, MEFV, MYD88, NFKB1, NLRC4, NLRP3, NOD1 (CARD4), RAC1, RELA, RIPK2, SLC11A1, TICAM2 (TRAM), TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TNF, TNFRSF1A, TOLLIP. Cytokines & Chemokines: CCL3 (MIP-1A), CCL5 (RANTES), CXCL1, CXCL2, IFNA1, IFNB1, IL12A, IL12B, IL18, IL1B, IL6, IL8. Antimicrobial Peptides: BPI, CAMP, CTSG, LCN2 (NGAL), LTF, LYZ, MPO, PRTN3, SLPI


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