阿爾茲海默癥PCR芯片 Alzheimer’s Disease PCR Array

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阿爾茲海默癥PCR芯片 Alzheimer’s Disease PCR Array

阿爾茲海默癥PCR芯片 Alzheimer’s Disease PCR Array
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地區(qū):上海
簡介:Alzheimer’s Disease PCR Array
提供商:SAB
服務(wù)名稱:Alzheimer’s Disease PCR Array
 Alzheimer’s Disease PCR Array阿爾茲海默癥PCR芯片
 
ProductSpeciesTechnologyCat. No.
Alzheimer's Disease PCR ArrayHumanGene ExpressionPAHS-057Z
Alzheimer's Disease PCR ArrayMouseGene ExpressionPAMM-057Z
Alzheimer's Disease PCR ArrayRatGene ExpressionPARN-057Z
阿爾茲海默癥PCR芯片包含了84個可用于研究老年癡呆癥發(fā)生與發(fā)展的重要基因。芯片中包括與β-淀粉樣蛋白(Aβ)的產(chǎn)生、清除和降解有關(guān)的基因,還包括β-淀粉樣蛋白(Aβ)信號轉(zhuǎn)導(dǎo)途徑中參與神經(jīng)毒性和炎癥反應(yīng)的基因。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測阿爾茲海默癥相關(guān)基因的表達。
Beta-Amyloid Generation, Oligomerization, Clearance, & Degradation: 
Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2. 
Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG. 
Endocytosis: APLP1, APP, LRP1, LRP6, LRP8. 
Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1.
Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI.
Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT.
Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB.
Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE , PRKCZ, PSEN1, PSEN2, SNCA.
Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA.
Cell Signaling Molecules: 
WNT Signaling: GSK3A, GSK3B, LRP6. 
Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2. 
G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2. 
Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2. 
Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA).
Transcription: APBB1, APBB2, EP300, ERN1.
Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2.
Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL, SERPINA3, UQCRC2


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