肺癌PCR芯片 Lung Cancer PCR Array
| 地區(qū)： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片 |
肺癌PCR芯片可用于研究與肺癌發(fā)展中關(guān)鍵的84個基因的表達。肺癌與吸煙、環(huán)境中的有害氣體以及病毒感染有關(guān)，但其中的分子機制還需要進一步研究。一些癌癥相關(guān)的基因調(diào)控了免疫反應，調(diào)亡，細胞周期，PI3K/AKT以及細胞黏附相關(guān)的通路。該芯片包含肺癌樣品中常規(guī)檢測的基因，啟動子發(fā)生甲基化變化的基因以及和腫瘤轉(zhuǎn)移相關(guān)的基因。利用實時定量PCR，研究者可以方便并且可信地對與肺癌發(fā)生發(fā)展以及轉(zhuǎn)移相關(guān)的基因進行同時檢測。 Differentially Methylated Promoters: APBA1, APC, CADM1, CDH1, CDH13, CDKN1C, CDKN2A, CDKN2B, CXCL12, CYP1B1, DLC1, FHIT, MGMT, MLH1, MTHFR, OPCML, PRDM2, RASSF1, RASSF2, SFRP1, TCF21. Metastatic Potential: ANXA5, DUSP6, ERBB3, HGF, HMMR, IRF4, LCK, MET, MMD, NF1, STAT1, STAT2. Differentially Expressed Genes in Adenocarcinoma (AC) Versus Squamous Cell Carcinoma (SCC): Higher in AC than in SCC: CLCA2, DSG3, KRT5, KRT14, SPRR1A. Higher in SCC than in AC: AGR2, LGSN, NKX2-1,SFTA3, SPINK1. Up-Regulated in Lung Cancer: CEACAM5, COL11A1, CP, CXCL13, GREM1, MKI67, MMP1, MMP12, SPINK1, SPP1, TOP2A, TOX3. Down-Regulated in Lung Cancer: AGER, CA4, CLDN18, CLIC5, FABP4, GPM6A, SCGB1A1, SFTPC, SOSTDC1, WIF1. PI3K/AKT Signaling: AKT1, BCL2, CDH1, CDKN2A, EGFR, NFKB1, TP53, VEGFA. Apoptosis: ANXA5, APC, BCL2, BIRC5, BRAF, CADM1, CDH1, CDH13, CDKN2A, DLC1, EGFR, ERBB2, ERBB3, HGF, HRAS, KRAS, LCK, MLH1, MMP9, NF1, NFKB1, PTGS2, SFRP1, STAT1, TERT, TGFB1, TNF, TOP2A, TP53, VEGFA. Cell Cycle Regulation: APC, BCL2, BIRC5, CDKN1C, CDKN2A, CDKN2B, EGFR, PTGS2, RB1, TGFB1, TNF, TP53. Immune Response: BCL2, CADM1, CSF3, CXCL12, CXCL13, IRF4, LCK, MLH1, MMD, NFKB1, PAX5, STAT1, STAT2, TGFB1, TNF, TP53, VEGFA. Extracellular Matrix & Cell Adhesion: CADM1, CDH1, CDH13, CEACAM6, CLDN18, COL11A1, DSG3, GPM6A, HMMR, KRT14, KRT5, MET, MMP1, MMP12, MMP9, SFTA3, SFTPC |
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