炎性PCR芯片 Inflammasomes PCR Array

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炎性PCR芯片 Inflammasomes PCR Array

炎性PCR芯片 Inflammasomes PCR Array
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簡介：Inflammasomes PCR Array炎性PCR芯片
提供商：SAbiosciences
服務(wù)名稱：炎性PCR芯片
地區(qū)：美國
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Inflammasomes PCR Array

炎性PCR芯片
 
ProductSpeciesTechnologyCat. No.
Inflammasomes PCR ArrayHumanGene ExpressionPAHS-097Z
Inflammasomes PCR ArrayMouseGene ExpressionPAMM-097Z
Inflammasomes PCR ArrayRatGene ExpressionPARN-097Z
The Human Inflammasomes RT2 Profiler? PCR Array profiles the expression of 84 key genes involved in the function of inflammasomes, protein complexes involved in innate immunity, as well as general NOD-like receptor (NLR) signaling. NLRs represent a major class of cytosolic pattern recognition receptors (PRR) that, like their cell-surface Toll-Like Receptor counterparts, recognize a wide variety of microbial pathogens and immunogenic biological products. Activation of one of four PRR family members (AIM2, NLRC4 or IPAF, NLRP1, and NLRP3) initiates the formation of an inflammasome. These protein complexes in turn activate caspase-1, leading to up-regulation of the pro-inflammatory cytokines IL1B and IL18 and pyroptosis, or caspase-1-dependent programmed cell death. This array includes genes encoding inflammasome components as well as genes involved in downstream signaling and inhibition of inflammasome function. In addition, this array includes other NLR family members, which may potentially form additional inflammasomes, and their downstream signaling genes. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes involved in inflammasome and NLR function and signaling with this array.
炎性PCR芯片檢測84個關(guān)鍵基因的表達(dá)，包括炎性體相關(guān)基因，先天免疫的蛋白復(fù)合物，以及一般的NOD樣受體（NLR）信號基因。NLRs是一類主要的胞漿內(nèi)模式識別受體（PRR），與細(xì)胞表面Toll樣受體一樣，識別多種多樣的病原微生物和免疫原性生物產(chǎn)物。PRR四個家庭成員（AIM2、NLRC4/IPAF、NLRP1和NLRP3）中任何一個的激活，都將引起炎性體的形成。而這些蛋白質(zhì)復(fù)合物又反向激活caspase-1，使促炎性細(xì)胞因子IL1B、IL18和pyroptosis上調(diào)，從而導(dǎo)致炎癥壞死，以及caspase-1依賴的程序性細(xì)胞死亡。芯片包括編碼炎性體組件的基因、炎性體功能發(fā)揮的下游信號和抑制基因、其他NLR家庭成員，以及可能形成更多的炎性體和其下游信號的基因。通過實(shí)時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測炎性體和NLR功能和信號相關(guān)的基因表達(dá).
Inflammasomes:
AIM2: AIM2, CASP1 (ICE), PYCARD (ASC).
IPAF: CASP1, NAIP, NLRC4 (IPAF), PYCARD (ASC).
NLRP1: CASP1 (ICE), CASP5, NLRP1.
NLRP3: CASP1 (ICE), NLRP3, PYCARD (ASC).
Negative Regulation: BCL2, BCL2L1 (BCL-X), CARD18 (ICEBERG), CD40LG (TNFSF5), CTSB, HSP90AA1, HSP90AB1, HSP90B1 (TRA1), MEFV, PSTPIP1, PYDC1 (POP1), SUGT1, TNF, TNFSF11, TNFSF14, TNFSF4 (OX40L).
Downstream Signaling: IFNG, IL12A, IL12B, IL18, IL1B, IL33, IRAK1, IRF1, MYD88, P2RX7, PANX1, PTGS2 (COX2), MOK, RIPK2, TIRAP, TXNIP.
NOD-Like Receptors:
Receptors: CIITA, NAIP (BIRC1), NLRC4 (IPAF), NLRC5, NLRP1, NLRP12, NLRP3, NLRP4, NLRP5, NLRP6, NLRP9, NLRX1, NOD1 (CARD4), NOD2.
Downstream Signaling: BIRC2 (c-IAP2), BIRC3 (c-IAP1), CARD6, CASP8 (FLICE), CCL2 (MCP-1), CCL5 (RANTES), CCL7 (MCP-3), CFLAR (CASPER), CHUK (IKKa), CXCL1, CXCL2, FADD, IFNB1, IKBKB, IKBKG, IL6, IRF1, IRF2, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK11, MAPK12, MAPK13, MAPK3 (ERK1), MAPK8 (JNK1), MAPK9 (JNK2), NFKB1, NFKBIA (I?Ba/MAD3), NFKBIB (TRIP9), PEA15, RELA, RIPK2, SUGT1, TAB1 (MAP3K7IP1), TAB2 (MAP3K7IP2), TNF, TRAF6, XIAP.
Pro-Inflammatory Caspases: CASP1 (ICE), CASP5


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