DNA修復(fù)甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
DNA修復(fù)甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
DNA修復(fù)甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
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DNA Repair EpiTect Methyl qPCR Array DNA修復(fù)甲基化PCR芯片
The Human DNA Repair EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 promoters of genes involved in DNA repair pathways such as base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. Hypermethylation-based silencing of these genes (BRCA1) increases mutation rates and tumor progression through the carcinogenic process. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into the role dysregulated DNA repair plays in diseases like cancer. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in DNA repair with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available. The EpiTect Methyl II PCR Arrays use the MethylScreen? Technology provided under license from Orion Genomics, LLC. DNA修復(fù)甲基化PCR芯片用于研究DNA修復(fù)途徑如基本切除修復(fù),核苷酸切除修復(fù)，錯(cuò)配修復(fù),雙鏈斷裂修復(fù)等相關(guān)的22個(gè)基因的啟動(dòng)子甲基化狀態(tài)。這些基于甲基化沉默的基因(BRCA1)通過致癌過程增加突變率和腫瘤進(jìn)展。利用這些芯片分析細(xì)胞或新鮮組織基因組DNA樣本有助于關(guān)聯(lián)CpG島甲基化狀態(tài)與生物表型。結(jié)果也可以幫助進(jìn)一步洞察DNA修復(fù)在癌癥等疾病種異表達(dá)的作用利用這個(gè)芯片，通過簡單的限制性內(nèi)切酶消化和實(shí)時(shí)定量PCR，就可以研究分析22個(gè)不同的DNA修復(fù)相關(guān)基因的啟動(dòng)子甲基化狀態(tài)。 提供96-孔板和384-孔板( 4 X 96 )。 Base Excision Repair (BER): APEX1, LIG3, PARP1, POLB, UNG, XRCC1. Nucleotide Excision Repair (NER): CCNH, RAD23A, RAD23B, XPC. Mismatch Repair (MMR): MLH1, MLH3, MSH2, PMS2, POLD3. Double-Strand Break (DSB) Repair: BRCA1, BRCA2, FEN1, MRE11A, RAD50, RAD51. Other Genes Related to DNA Repair: ATM |
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